Association of Compliance and Quality the Impact of Antiretroviral Administration During the COVID-19 Pandemic in HIV/AIDS Patients: A Hosptial Based Study in Indonesia

Acquired Immune Deficiency Syndrome (AIDS) is a collection of symptoms that arise due to a decrease in the human immune system, caused by the Human Immunodeficiency Virus (HIV). Impact of people living with HIV/AIDS (PLWHA) will experience physical, psychological, social and spiritual problems. Antiretroviral drugs are given to prevent the replication of the HIV virus in CD4 cells, but high adherence is required to achieve suppression of the HIV virus. The aim of this study was to determine the association of compliance and quality with the impact of antiretroviral administration during the COVID-19 pandemic in HIV/AIDS patients. The type of research used is cross-sectional study design. The research sample amounted to 104 PLWHA who carried out control at the polyclinic of Dr. M. Djamil Hospital Padang. The sampling technique used is convenience sampling. The research instrument used was the simplified self-report measure of adherence questionnaire and a study of documentation on the patient's medical record. Data analysis used Chi-square test. P < 0.05 was significant, and the data were analyzed using the SPSS version 21.0 program. Most subjects were aged 18-40 years (61.53%) with male (81.7%). The highest educational background was found in high school seniors (49.0%) and married (43.28%). More than half of the subjects were homosexual (45.2%) and family known HIV status (79.9%). A small number of subjects had a history of COVID-19 infection (13.5%) and more than half of the subjects had COVID-19 vaccination status < 2 times (65.39%). Less than half of the subjects had decreased weight gain (18.03%). In subjects who did not comply with taking ARV drugs (23.1%), viral load was not detected (67.3%) and had an increased CD4 cell count (88.5%). The results of the study found that there was a significant relationship with medication adherence with CD4 count, body weight, and viral load (p<0.05). It is hoped that health workers will always provide education about the importance of being obedient to taking ARV drugs regularly and support from all parties so that opportunistic infections do not occur, CD4 increases and Viral load is not detected in PLWHA.